Spironolactone mice

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We assessed whether blockade of mineralocorticoid receptors (MR) with spironolactone decreases reactive oxygen species (ROS)-associated vascular dysfunction and improves vascular nitric oxide (NO) signaling in diabetes. Leptin receptor knockout [LepRdb/LepRdb (db/db)] mice, a model of DM2, and  ‎Introduction · ‎Materials and methods · ‎Results · ‎Discussion. J Urol. Oct;(4 Pt 2) Prevention of renal fibrosis by spironolactone in mice with complete unilateral ureteral obstruction. Trachtman H(1), Weiser AC, Valderrama E, Morgado M, Palmer LS. Author information: (1)Department of Pediatrics, Schneider Children's Hospital, New Hyde Park, New York , USA.

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Klotho is a potent regulator of 1,hydroxyvitamin D3 [1,25(OH)2D3] formation and calcium-phosphate metabolism. Klotho-hypomorphic mice (kl/kl mice) suffer from severe growth deficits, rapid aging, hyperphosphatemia, hyperaldosteronism, and extensive vascular and soft tissue calcification. Sequelae  ‎Introduction · ‎Results · ‎Discussion · ‎Methods. Complete unilateral ureteral obstruction (UUO) was created surgically in 8 to week-old male C57BL/6 mice by placing sutures around the right ureter. Spironolactone (50 mg/kg/daily) or 1% dimethyl sulfoxide vehicle was administered by subcutaneous injection for 1 to 2 weeks, and renal fibrosis was assessed by.

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