Should fosamax be stopped after 5 years

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Duration of treatment and possible discontinuation should be personalized for patients based on their response to treatment, fracture risk, and comorbidities. .. Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-Term Extension (FLEX): a randomized trial. JAMA. An FDA review of clinical studies measuring the effectiveness of long-term bisphosphonates use shows that some patients may be able to stop using bisphosphonates after three to five years and still continue to benefit from their use, says Marcea Whitaker, M.D., a medical officer at FDA's Center for Drug Evaluation and.

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Effects of Continuing or Stopping Alendronate After 5 Years of TreatmentThe Fracture Intervention Trial Long-term Extension (FLEX): A Randomized Trial. Dennis M. Black .. Therefore, our results should not be generalized to shorter treatment periods or longer periods without treatment. Despite these. Oral bisphosphonates should also be avoided after certain types of bariatric surgery in which surgical anastomoses are present in the GI tract (eg, . Alendronate — For some women, stopping alendronate after five years is reasonable as there appears to be a residual benefit on BMD and fractures for up to.

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